Synapse assembly

Across TCGA patient cohorts, RNA activity of the Synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MBD5, BOD1L1, and ZC3H7B, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synapse assembly activity versus MBD5 in THYM (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	MBD5 →	+0.765	+0.025	<.001	<.001	3	31
THYM	BOD1L1 →	+1.313	+0.027	<.001	<.001	3	30
THYM	ZC3H7B →	+1.333	+0.032	<.001	<.001	3	29
SCLC	MEGF8 →	+0.958	+0.077	.001	<.001	3	29
THYM	PRPF40B →	+1.368	+0.034	<.001	<.001	3	29
THYM	PRRC2B →	+1.731	+0.032	<.001	<.001	3	29

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007416 vs MBD5 — THYM

Explore this scatter interactively →