Synapse assembly

Across TCGA patient cohorts, RNA activity of the Synapse assembly pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RASAL3, SOX4_S354, and CD2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synapse assembly activity versus RASAL3 in LSCC (Pearson r = -0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RASAL3 →	-0.444	-0.034	<.001	<.001	3	8
LUAD	SOX4_S354 →	+0.652	+0.031	<.001	<.001	3	7
LSCC	CD2 →	-0.581	-0.030	<.001	<.001	3	7
LSCC	ITGAL →	-0.517	-0.023	<.001	<.001	3	7
LSCC	PSD4 →	-0.357	-0.026	<.001	<.001	3	7
HNSC	LTBP3 →	+0.488	+0.036	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007416 vs RASAL3 — LSCC

Explore this scatter interactively →