Synapse assembly

Across TCGA cell cohorts, RNA activity of the Synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8B1, YBEY, and MRI1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Synapse assembly activity versus ATP8B1 in LARGE_INTESTINE (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ATP8B1 →	+1.329	+0.402	.004	.003	3	4
BLOOD_Lymphoma	YBEY →	+0.922	+0.281	.001	.001	3	3
BLOOD_Lymphoma	MRI1 →	+0.769	+0.237	.003	<.001	3	3
LUNG_NSCLC_LUSC	PPIL2 →	+1.087	+0.454	.003	.001	3	3
LUNG_NSCLC_LUSC	MVD →	+1.040	+0.513	.001	<.001	3	3
LARGE_INTESTINE	LDHD →	+0.788	+0.290	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007416 vs ATP8B1 — LARGE_INTESTINE

Explore this scatter interactively →