Axonal fasciculation

Across TCGA patient cohorts, RNA activity of the Axonal fasciculation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCL2A1, PLAT, and LAMP5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonal fasciculation activity versus BCL2A1 in BRCA (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BCL2A1 →	-1.007	-0.626	.003	.001	3	5
UCEC	PLAT →	+1.082	+1.044	<.001	<.001	3	5
BRCA	LAMP5 →	+0.850	+0.676	.001	<.001	3	4
BRCA	CX3CR1 →	+1.583	+0.745	<.001	<.001	3	4
BRCA	AXIN2 →	+0.558	+0.517	.004	.009	3	4
BRCA	TRAM1L1 →	+0.903	+0.819	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007413 vs BCL2A1 — BRCA

Explore this scatter interactively →