Axonal fasciculation

Across TCGA cell cohorts, RNA activity of the Axonal fasciculation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STARD5, DZIP1L, and PIGK, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STARD5 grouped by Axonal fasciculation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	STARD5 →	+1.337	+0.987	<.001	<.001	3	4
CNS	DZIP1L →	+0.438	+1.542	.006	<.001	3	4
SOFT_TISSUE	PIGK →	+1.087	+0.935	<.001	.002	3	3
LUNG_NSCLC_LUAD	TXNIP →	+2.735	+0.785	.001	.002	3	3
LUNG_NSCLC_LUAD	DPYSL3 →	+2.015	+0.673	<.001	.009	3	3
LUNG_NSCLC_LUAD	B2M →	+0.632	+0.595	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STARD5 by Axonal fasciculation activity — OESOPHAGUS

Explore this box plot interactively →