Axonal fasciculation

Across TCGA cell cohorts, RNA activity of the Axonal fasciculation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASL, MTURN, and SLC43A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axonal fasciculation activity versus ASL in BLOOD_Leukemia (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASL →	-1.840	-0.212	<.001	.004	3	5
BLOOD_Leukemia	MTURN →	-1.477	-0.180	<.001	.002	3	5
LARGE_INTESTINE	SLC43A1 →	-1.457	-0.162	.008	.009	3	5
CNS	ADAMTSL5 →	-1.322	-0.156	.005	.002	3	4
SOFT_TISSUE	DKK1 →	+5.503	+0.296	<.001	<.001	3	4
BLOOD_Leukemia	LGALS3BP →	+3.329	+0.225	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007413 vs ASL — BLOOD_Leukemia

Explore this scatter interactively →