Axon guidance

Across TCGA patient cohorts, RNA activity of the Axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZEB1, TAL1, and ZCCHC24, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon guidance activity versus ZEB1 in OV (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZEB1 →	+1.488	+0.381	<.001	<.001	3	5
BRCA	TAL1 →	+0.524	+1.317	.001	<.001	3	5
BRCA	ZCCHC24 →	+1.084	+1.477	<.001	<.001	3	5
BRCA	AXL →	+0.872	+1.271	<.001	<.001	3	5
BRCA	FCER1A →	+1.608	+1.236	<.001	<.001	3	5
OV	DDR2 →	+1.981	+0.562	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007411 vs ZEB1 — OV

Explore this scatter interactively →