Axon guidance

Across TCGA cell cohorts, RNA activity of the Axon guidance pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPM, LDLR, and TNFRSF21, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Axon guidance activity versus CPM in STOMACH (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CPM →	+2.153	+0.184	.003	.004	3	6
LARGE_INTESTINE	LDLR →	+1.201	+0.304	<.001	<.001	3	5
OESOPHAGUS	TNFRSF21 →	+1.787	+0.201	.006	.009	3	5
BLOOD_Myeloma	COTL1 →	+4.707	+0.302	<.001	.001	3	5
STOMACH	PLAU →	+4.017	+0.194	.003	.002	2	6
SOFT_TISSUE	ITGB2 →	+2.155	+0.316	.002	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007411 vs CPM — STOMACH

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