Negative regulation of neuroblast proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of neuroblast proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATRX, MYEF2, and PTN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuroblast proliferation activity versus ATRX in UCEC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATRX →	+0.214	+0.129	.002	<.001	3	6
BRCA	MYEF2 →	+0.495	+0.074	.004	<.001	3	6
BRCA	PTN →	+1.069	+0.083	<.001	<.001	3	6
UCEC	CEP68 →	+0.302	+0.124	<.001	<.001	3	6
BRCA	EPM2AIP1 →	+0.452	+0.081	.001	<.001	3	6
HNSC	RCOR3 →	+0.378	+0.116	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007406 vs ATRX — UCEC

Explore this scatter interactively →