Negative regulation of neuroblast proliferation

Across TCGA patient cohorts, RNA activity of the Negative regulation of neuroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRCA1P1, LINC02702, and ZNF207, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuroblast proliferation activity versus BRCA1P1 in UCEC (Pearson r = 0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BRCA1P1 →	+1.102	+0.618	.001	.001	3	4
COAD	LINC02702 →	+0.031	+0.751	.004	.006	3	3
BRCA	ZNF207 →	+0.377	+0.629	<.001	<.001	3	3
BRCA	GOSR2 →	+0.285	+0.579	.001	.003	3	3
BRCA	C17orf75 →	+0.370	+0.570	<.001	<.001	3	3
BRCA	PEX12 →	+0.458	+0.575	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007406 vs BRCA1P1 — UCEC

Explore this scatter interactively →