Negative regulation of neuroblast proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of neuroblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERCC3, CWC22, and KLHDC8B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERCC3 grouped by Negative regulation of neuroblast proliferation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ERCC3 →	+0.687	+1.434	.002	.005	3	5
OESOPHAGUS	CWC22 →	+0.660	+1.368	.005	.001	3	4
LUNG_NSCLC_LUSC	KLHDC8B →	-2.132	-1.785	.006	.001	3	4
STOMACH	PKN1 →	+1.281	+1.467	.004	<.001	3	4
KIDNEY	OLA1 →	+0.602	+1.230	.003	<.001	3	4
PANCREAS	CCDC59 →	+0.744	+1.145	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERCC3 by Negative regulation of neuroblast proliferation activity — OESOPHAGUS

Explore this box plot interactively →