Compartment pattern specification

pathway activity — cross-omics
GO:0007386Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Compartment pattern specification pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNRIP1, CEBPZ_S629, and COL14A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCACNRIP1 →+0.624+0.067<.001<.00137
UCECCEBPZ_S629 →-0.490-0.072<.001<.00137
BRCACOL14A1 →+0.649+0.051<.001<.00137
GBMRPL5 →-0.225-0.121<.001<.00136
OVSEPTIN4 →+0.549+0.058.001.00336
BRCASSC5D →+0.635+0.064<.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration