Segment specification

Across TCGA patient cohorts, RNA activity of the Segment specification pathway is significantly associated with the RNA expression of multiple genes, with the THYM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLL1, MLLT3, and CHD2, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Segment specification activity versus DLL1 in THYM (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	DLL1 →	+1.625	+0.096	<.001	<.001	3	24
DLBC	MLLT3 →	+0.904	+0.067	<.001	<.001	3	21
DLBC	CHD2 →	+0.957	+0.070	<.001	.002	3	21
THYM	MDN1 →	+0.602	+0.069	<.001	<.001	3	20
THYM	NAA16 →	+0.869	+0.092	<.001	<.001	3	20
TGCT	AGO3 →	+0.755	+0.076	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007379 vs DLL1 — THYM

Explore this scatter interactively →