Segment specification

Across TCGA patient cohorts, RNA activity of the Segment specification pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COBL, TMEM125, and FAAH, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Segment specification activity versus COBL in UCEC (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	COBL →	+0.922	+0.295	<.001	<.001	3	7
LSCC	TMEM125 →	+1.252	+0.438	<.001	<.001	3	6
LUAD	FAAH →	+0.606	+0.294	<.001	.001	3	5
PDAC	GATM →	+0.925	+0.179	<.001	.001	3	5
CCRCC	RNFT1P2 →	+0.808	+0.318	.001	.002	3	5
CCRCC	C1orf210 →	+1.074	+0.291	.004	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007379 vs COBL — UCEC

Explore this scatter interactively →