Segment specification

Across TCGA cell cohorts, RNA activity of the Segment specification pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FTL, MRPL50, and RAB24, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FTL grouped by Segment specification-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	FTL →	-0.973	-1.691	.007	.003	3	4
LUNG_NSCLC_LUAD	MRPL50 →	+0.469	+0.990	.001	<.001	3	4
LUNG_NSCLC_LUAD	RAB24 →	-0.426	-0.696	.008	.001	3	4
SOFT_TISSUE	PLAAT4 →	-2.348	-1.427	<.001	<.001	3	4
PANCREAS	REEP3 →	-1.146	-1.355	<.001	<.001	3	4
BREAST	MRPL44 →	+0.526	+0.758	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FTL by Segment specification activity — BONE

Explore this box plot interactively →