Segment specification

Across TCGA cell cohorts, RNA activity of the Segment specification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE3B, U2AF1L4, and ALKBH6, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Segment specification activity versus UBE3B in LUNG_SCLC (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	UBE3B →	+0.530	+0.324	.002	.002	3	2
LUNG_SCLC	U2AF1L4 →	+1.047	+0.319	.006	.002	3	2
LUNG_SCLC	ALKBH6 →	+1.138	+0.286	.001	.001	3	2
STOMACH	WWTR1 →	+4.550	+0.657	<.001	.002	3	2
LUNG_SCLC	EHD4 →	-1.122	-0.269	.004	.008	3	1
LUNG_SCLC	ZNHIT1 →	+0.617	+0.252	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007379 vs UBE3B — LUNG_SCLC

Explore this scatter interactively →