Gastrulation

Across TCGA cell cohorts, RNA activity of the Gastrulation pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP23, DSE, and COQ8A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gastrulation activity versus ARHGAP23 in SKIN (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ARHGAP23 →	+1.691	+0.270	<.001	<.001	3	6
SKIN	DSE →	+1.435	+0.294	.001	<.001	3	6
LUNG_NSCLC_LUAD	COQ8A →	-0.897	-0.175	<.001	.003	3	6
SOFT_TISSUE	DPYD →	+3.162	+0.370	.006	.003	3	6
BREAST	PLAU →	+2.880	+0.310	.003	.007	2	7
BONE	CAVIN3 →	+5.468	+0.543	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007369 vs ARHGAP23 — SKIN

Explore this scatter interactively →