Thorax and anterior abdomen determination

Across TCGA patient cohorts, RNA activity of the Thorax and anterior abdomen determination pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BASP1, MAGI2-AS3, and DCN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Thorax and anterior abdomen determination activity versus BASP1 in HNSC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	BASP1 →	+1.399	+0.606	<.001	.003	2	7
CCRCC	MAGI2-AS3 →	+0.573	+0.649	.006	.001	3	6
CCRCC	DCN →	+2.915	+0.833	<.001	<.001	3	5
CCRCC	MMP2 →	+1.640	+0.804	<.001	<.001	3	5
OV	ABCA6 →	+0.652	+0.615	.003	.004	3	5
CCRCC	MAP1A →	+0.621	+0.460	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007356 vs BASP1 — HNSC

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