"Zygotic determination of anterior/posterior axis, embryo"

Across TCGA patient cohorts, RNA activity of the "Zygotic determination of anterior/posterior axis, embryo" pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITGB1_T777, BASP1, and FSCN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Zygotic determination of anterior/posterior axis, embryo" activity versus ITGB1_T777 in OV (Pearson r = 0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ITGB1_T777 →	+0.584	+0.105	.006	.008	2	8
UCEC	BASP1 →	+0.747	+0.223	<.001	<.001	3	6
COAD	FSCN1 →	+0.497	+0.070	.001	.001	3	6
OV	FSCN1_S39 →	+0.671	+0.095	<.001	<.001	3	6
OV	SEC23A →	+0.372	+0.136	<.001	<.001	3	6
OV	CRTAP →	+0.456	+0.100	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007354 vs ITGB1_T777 — OV

Explore this scatter interactively →