"Zygotic determination of anterior/posterior axis, embryo"

Across TCGA cell cohorts, RNA activity of the "Zygotic determination of anterior/posterior axis, embryo" pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EIF2S2, DNAJC8, and TBCA, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EIF2S2 grouped by "Zygotic determination of anterior/posterior axis, embryo"-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EIF2S2 →	-0.923	-1.167	.009	.006	3	3
STOMACH	DNAJC8 →	-0.444	-0.911	.003	.005	3	3
UPPER_AERODIGESTIVE_TRACT	TBCA →	-1.038	-0.395	.002	.008	3	3
UPPER_AERODIGESTIVE_TRACT	H2AC14 →	-1.341	-0.389	.003	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	DEPDC1B →	-1.876	-0.478	.007	.002	3	3
STOMACH	POLR2G →	-0.626	-0.942	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EIF2S2 by "Zygotic determination of anterior/posterior axis, embryo" activity — STOMACH

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