Egg activation

Across TCGA patient cohorts, RNA activity of the Egg activation pathway is significantly associated with the RNA expression of multiple genes, with the CESC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAT, NPR2, and MYOF, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Egg activation activity versus PLAT in CESC (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	PLAT →	+2.800	+0.166	<.001	<.001	3	29
ACC	NPR2 →	+1.683	+0.087	<.001	.001	3	26
THYM	MYOF →	+1.512	+0.038	<.001	<.001	3	20
SCLC	MYH9 →	+1.119	+0.138	<.001	.003	1	21
SARC	MYH11 →	+3.333	+0.062	<.001	<.001	3	19
SCLC	TLN1 →	+1.053	+0.147	<.001	<.001	2	20

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007343 vs PLAT — CESC

Explore this scatter interactively →