Egg activation

Across TCGA patient cohorts, RNA activity of the Egg activation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAT, MICAL2, and SYNJ2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Egg activation activity versus PLAT in BRCA (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PLAT →	+1.080	+0.094	<.001	<.001	3	9
LSCC	MICAL2 →	+0.490	+0.158	<.001	<.001	3	6
UCEC	SYNJ2 →	+0.253	+0.068	.003	.008	3	6
OV	COL5A2 →	+0.530	+0.057	<.001	<.001	3	6
UCEC	FHL2 →	+0.765	+0.107	<.001	<.001	3	6
LSCC	RBMS2 →	+0.256	+0.101	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007343 vs PLAT — BRCA

Explore this scatter interactively →