Egg activation

Across TCGA cell cohorts, RNA activity of the Egg activation pathway is significantly associated with the drug response of multiple features, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are NU7441, BMS-536924, and Methotrexate, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NU7441 grouped by Egg activation-low versus -high activity in SKIN.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NU7441 →	-1.048	-0.169	.018	.019	3	2
SKIN	BMS-536924 →	+0.896	+0.195	.013	.022	2	2
SKIN	Methotrexate →	+1.705	+0.181	<.001	.009	3	1
SKIN	IAP_7638 →	+0.786	+0.230	.011	.014	3	1
SKIN	QS11 →	+0.610	+0.185	.010	.013	3	1
SKIN	GSK2110183B →	-0.946	-0.220	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NU7441 by Egg activation activity — SKIN

Explore this box plot interactively →