Penetration of zona pellucida

Across TCGA cell cohorts, RNA activity of the Penetration of zona pellucida pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACR, HYAL3, and TNP2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACR grouped by Penetration of zona pellucida-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ACR →	-0.470	-1.579	.008	.005	3	12
OVARY	HYAL3 →	-0.249	-1.373	.001	.002	3	8
STOMACH	TNP2 →	-0.207	-1.478	.005	<.001	2	7
KIDNEY	GAN →	-0.143	-1.142	<.001	.002	2	6
SOFT_TISSUE	CDH10 →	-0.160	-1.325	<.001	.005	3	5
LUNG_SCLC	UBR3 →	-0.190	-1.674	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACR by Penetration of zona pellucida activity — SOFT_TISSUE

Explore this box plot interactively →