Acrosome reaction

Across TCGA patient cohorts, RNA activity of the Acrosome reaction pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRN2, NOSTRIN, and TADA2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acrosome reaction activity versus PTPRN2 in GBM (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTPRN2 →	+0.777	+0.732	<.001	<.001	3	5
BRCA	NOSTRIN →	+0.700	+0.407	.006	.003	3	4
BRCA	TADA2B →	+0.499	+0.582	.001	.009	3	4
BRCA	FAM174B →	+0.647	+0.397	.002	.004	3	4
BRCA	INKA2 →	+0.357	+0.394	.001	.005	3	4
GBM	EEF1A2 →	+1.198	+0.719	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007340 vs PTPRN2 — GBM

Explore this scatter interactively →