Acrosome reaction

Across TCGA cell cohorts, RNA activity of the Acrosome reaction pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCL2, GTF3C4, and SNAPC4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLCL2 grouped by Acrosome reaction-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PLCL2 →	+1.062	+1.420	.001	<.001	3	4
BLOOD_Myeloma	GTF3C4 →	+1.487	+1.834	.005	.001	3	4
BLOOD_Myeloma	SNAPC4 →	+1.105	+1.755	.003	.005	3	4
LUNG_NSCLC_LUSC	HSD11B2 →	+1.886	+1.441	.009	.004	3	4
STOMACH	CCDC43 →	+0.611	+1.575	<.001	<.001	3	4
BLOOD_Leukemia	HTR2B →	+0.295	+0.965	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLCL2 by Acrosome reaction activity — OVARY

Explore this box plot interactively →