Acrosome reaction

Across TCGA cell cohorts, RNA activity of the Acrosome reaction pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BTF3, SCNN1D, and MEOX1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Acrosome reaction activity versus BTF3 in CNS (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	BTF3 →	-0.918	-0.376	.001	.007	3	1
CNS	SCNN1D →	-1.350	-0.376	.009	.007	3	1
CNS	MEOX1 →	-0.464	-0.376	.009	.007	3	1
CNS	MRPS18A →	-0.509	-0.376	.003	.007	3	1
SKIN	VWA8 →	-0.732	-0.424	<.001	.002	3	1
SKIN	PLEKHJ1 →	-0.730	-0.424	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007340 vs BTF3 — CNS

Explore this scatter interactively →