Acrosome reaction

Across TCGA cell cohorts, RNA activity of the Acrosome reaction pathway is significantly associated with the drug response of multiple features, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are alpha-lipoic acid, VX-702, and MG-132, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, alpha-lipoic acid grouped by Acrosome reaction-low versus -high activity in SKIN.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	alpha-lipoic acid →	-0.640	-0.400	.028	.015	3	3
BONE	VX-702 →	-0.519	-1.693	.014	.009	3	2
CNS	MG-132 →	-0.433	-0.378	.011	.018	3	2
CNS	Bryostatin 1 →	+0.399	+0.386	.010	.015	3	2
CNS	kb NB 142-70 →	-0.443	-0.350	.026	.023	3	2
CNS	CAY10566 →	-0.440	-0.480	.027	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

alpha-lipoic acid by Acrosome reaction activity — SKIN

Explore this box plot interactively →