Binding of sperm to zona pellucida

Across TCGA patient cohorts, RNA activity of the Binding of sperm to zona pellucida pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA4, DDX21, and ZEB2, each associated with the pathway in up to 28 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Binding of sperm to zona pellucida activity versus ITGA4 in DLBC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	ITGA4 →	+1.429	+0.078	<.001	<.001	3	28
DLBC	DDX21 →	+1.430	+0.095	<.001	<.001	3	28
MESO	ZEB2 →	+1.227	+0.042	<.001	.001	3	28
DLBC	RIC1 →	+0.949	+0.076	<.001	<.001	3	27
DLBC	STAG1 →	+1.194	+0.092	<.001	<.001	3	27
MESO	CD93 →	+1.691	+0.050	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007339 vs ITGA4 — DLBC

Explore this scatter interactively →