Binding of sperm to zona pellucida

Across TCGA patient cohorts, RNA activity of the Binding of sperm to zona pellucida pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STX4, REEP6, and DCTPP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Binding of sperm to zona pellucida activity versus STX4 in UCEC (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STX4 →	-0.278	-0.073	.004	.004	3	6
BRCA	REEP6 →	-1.381	-0.077	<.001	<.001	3	6
BRCA	DCTPP1 →	-0.550	-0.062	.004	.001	3	6
UCEC	BSG →	-0.355	-0.093	<.001	<.001	3	5
LSCC	THEMIS2 →	+0.443	+0.079	<.001	<.001	3	5
OV	TKFC →	-0.412	-0.059	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007339 vs STX4 — UCEC

Explore this scatter interactively →