Binding of sperm to zona pellucida

Across TCGA patient cohorts, RNA activity of the Binding of sperm to zona pellucida pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMD4A, PIK3IP1, and ENPP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Binding of sperm to zona pellucida activity versus SAMD4A in LSCC (Pearson r = -0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMD4A →	-0.786	-0.114	<.001	.003	3	4
GBM	PIK3IP1 →	-0.504	-0.071	.007	.001	3	4
PDAC	ENPP2 →	-0.413	-0.102	.002	.005	3	4
CCRCC	ZNF444 →	-0.196	-0.106	.005	.005	3	3
UCEC	NEXN →	-0.832	-0.191	.004	.004	3	3
UCEC	MIR4477B →	-1.277	-0.220	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007339 vs SAMD4A — LSCC

Explore this scatter interactively →