Binding of sperm to zona pellucida

Across TCGA cell cohorts, RNA activity of the Binding of sperm to zona pellucida pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZC2HC1A, KCNJ11, and SPATA20, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZC2HC1A grouped by Binding of sperm to zona pellucida-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZC2HC1A →	-1.841	-0.315	.005	.002	3	3
SKIN	KCNJ11 →	-0.176	-0.403	.004	.006	3	3
SKIN	SPATA20 →	-0.684	-0.408	.002	.007	3	3
CNS	TSPAN33 →	+1.017	+0.531	.007	.002	3	3
BLOOD_Lymphoma	VAMP4 →	+0.854	+0.412	.004	.002	3	3
BLOOD_Leukemia	C4orf33 →	+0.843	+0.430	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZC2HC1A by Binding of sperm to zona pellucida activity — SOFT_TISSUE

Explore this box plot interactively →