Binding of sperm to zona pellucida

Across TCGA cell cohorts, RNA activity of the Binding of sperm to zona pellucida pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PFDN2, MRPL24, and CHD1L, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Binding of sperm to zona pellucida activity versus PFDN2 in BLOOD_Myeloma (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PFDN2 →	+1.302	+0.153	.001	.003	3	6
BLOOD_Myeloma	MRPL24 →	+1.054	+0.149	<.001	<.001	3	6
SKIN	CHD1L →	+0.658	+0.130	.003	.004	3	5
BLOOD_Myeloma	CERS2 →	+1.550	+0.190	.001	<.001	3	5
SKIN	MDH2 →	+1.333	+0.195	<.001	<.001	3	5
SKIN	TOMM40L →	+0.819	+0.179	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007339 vs PFDN2 — BLOOD_Myeloma

Explore this scatter interactively →