Single fertilization

Across TCGA patient cohorts, RNA activity of the Single fertilization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP9, RAB27B, and HID1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Single fertilization activity versus AKAP9 in BRCA (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	AKAP9 →	+0.206	+0.017	.009	.004	3	6
PDAC	RAB27B →	+0.397	+0.024	.003	.002	3	6
COAD	HID1 →	+0.394	+0.021	.005	.001	3	5
HNSC	THYN1 →	-0.211	-0.022	.004	.002	3	4
HNSC	DNMBP →	+0.301	+0.034	.001	.001	3	4
PDAC	EFEMP1 →	-0.589	-0.030	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007338 vs AKAP9 — BRCA

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