Single fertilization

Across TCGA patient cohorts, RNA activity of the Single fertilization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPG, LINC01943, and MTPAP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Single fertilization activity versus CAPG in BRCA (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAPG →	-0.423	-0.116	.008	<.001	3	5
BRCA	LINC01943 →	-0.489	-0.147	.002	.001	3	5
LSCC	MTPAP →	+0.364	+0.071	<.001	<.001	3	5
GBM	ARFGEF3 →	+0.750	+0.067	.001	.005	3	4
HNSC	SAMD12 →	+0.844	+0.059	.002	.006	3	4
GBM	FAM162B →	+0.407	+0.053	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007338 vs CAPG — BRCA

Explore this scatter interactively →