Single fertilization

Across TCGA cell cohorts, RNA activity of the Single fertilization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COQ8A, KANSL1L, and GATD3A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COQ8A grouped by Single fertilization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	COQ8A →	-1.366	-0.407	.001	.003	3	4
STOMACH	KANSL1L →	-0.990	-0.266	.001	<.001	3	3
LUNG_SCLC	GATD3A →	-1.697	-0.202	.001	.004	3	3
LUNG_SCLC	LAMP1 →	-0.924	-0.192	.004	.002	2	4
PANCREAS	SGK1 →	-2.652	-0.343	.003	.002	3	3
PANCREAS	PTGFRN →	-2.256	-0.356	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COQ8A by Single fertilization activity — SOFT_TISSUE

Explore this box plot interactively →