Insemination

Across TCGA patient cohorts, RNA activity of the Insemination pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP12, AKAP12_S286, and PALMD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Insemination activity versus AKAP12 in GBM (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AKAP12 →	+0.581	+0.070	<.001	.002	3	5
BRCA	AKAP12_S286 →	+0.923	+0.041	.001	.003	3	5
BRCA	PALMD →	+0.687	+0.055	<.001	<.001	3	5
BRCA	SOD3 →	+0.809	+0.039	.002	.008	2	5
BRCA	VIM →	+0.424	+0.047	<.001	<.001	3	4
LSCC	VIM_T20 →	+0.462	+0.070	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007320 vs AKAP12 — GBM

Explore this scatter interactively →