Insemination

Across TCGA cell cohorts, RNA activity of the Insemination pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRS3, NAT14, and DLD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRS3 grouped by Insemination-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	BRS3 →	+0.125	+0.155	.004	.001	3	5
PANCREAS	NAT14 →	-0.338	-1.677	.003	.007	3	3
BLOOD_Lymphoma	DLD →	-0.270	-0.306	.001	.002	3	3
BLOOD_Lymphoma	JAG1 →	+0.235	+0.261	.003	.003	3	3
BLOOD_Lymphoma	GEM →	-0.418	-0.274	<.001	<.001	3	3
SOFT_TISSUE	ABCF3 →	-0.324	-0.192	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRS3 by Insemination activity — BLOOD_Leukemia

Explore this box plot interactively →