Pole plasm assembly

Across TCGA patient cohorts, RNA activity of the Pole plasm assembly pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLD6, TDRKH, and NAXE, each associated with the pathway in up to 30 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pole plasm assembly activity versus PLD6 in ACC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	PLD6 →	+1.293	+0.078	<.001	<.001	3	30
TGCT	TDRKH →	+0.955	+0.078	<.001	<.001	3	23
SCLC	NAXE →	+0.618	+0.719	<.001	<.001	3	22
TGCT	PDCD2L →	+0.618	+0.061	<.001	<.001	3	20
TGCT	CCT7 →	+0.495	+0.062	.001	<.001	3	20
LAML	C1orf162 →	-0.905	-0.062	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007315 vs PLD6 — ACC

Explore this scatter interactively →