Pole plasm assembly

Across TCGA patient cohorts, RNA activity of the Pole plasm assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VCL, ADAR, and GPATCH4_S135, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pole plasm assembly activity versus VCL in UCEC (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VCL →	-0.595	-0.070	<.001	<.001	3	6
BRCA	ADAR →	+0.291	+0.050	<.001	<.001	3	6
BRCA	GPATCH4_S135 →	+0.525	+0.046	.002	<.001	3	6
LSCC	TNKS1BP1 →	-0.302	-0.092	<.001	<.001	3	6
LSCC	USP42_S1007 →	+0.508	+0.077	<.001	<.001	3	5
CCRCC	PPP1R12A_S507 →	-0.437	-0.046	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007315 vs VCL — UCEC

Explore this scatter interactively →