Pole plasm assembly

Across TCGA patient cohorts, RNA activity of the Pole plasm assembly pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS15P5, HDAC11-AS1, and CCDC146, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pole plasm assembly activity versus RPS15P5 in HNSC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RPS15P5 →	-0.657	-0.631	.001	<.001	3	3
OV	HDAC11-AS1 →	-0.175	-0.538	.002	.003	3	3
BRCA	CCDC146 →	-0.621	-0.692	<.001	<.001	3	3
BRCA	COL6A2 →	-1.155	-0.635	<.001	<.001	3	3
BRCA	RNU5B-2P →	-0.761	-0.561	.001	.004	3	3
BRCA	NPM1P33 →	-0.146	-0.513	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007315 vs RPS15P5 — HNSC

Explore this scatter interactively →