Pole plasm assembly

Across TCGA cell cohorts, RNA activity of the Pole plasm assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCH, FMNL2, and PLCXD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKCH grouped by Pole plasm assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRKCH →	-2.568	-1.309	.003	.007	3	4
BLOOD_Leukemia	FMNL2 →	-3.803	-2.056	<.001	<.001	3	4
LUNG_SCLC	PLCXD2 →	-1.532	-0.863	.005	.008	3	4
LUNG_SCLC	RILPL2 →	+1.109	+0.823	.009	.007	3	4
URINARY_TRACT	ABHD2 →	+1.654	+1.599	.002	.002	3	4
BLOOD_Leukemia	TMEM45A →	+2.203	+1.458	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKCH by Pole plasm assembly activity — BLOOD_Leukemia

Explore this box plot interactively →