Pole plasm assembly

Across TCGA cell cohorts, RNA activity of the Pole plasm assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAH, KCNE3, and CILK1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAH grouped by Pole plasm assembly-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FAH →	-0.420	-1.588	<.001	<.001	3	2
BREAST	KCNE3 →	-0.145	-1.645	.005	.006	3	2
LARGE_INTESTINE	CILK1 →	+0.165	+1.645	.004	.002	3	1
LARGE_INTESTINE	GATA6 →	+0.280	+1.735	.008	.003	3	1
LARGE_INTESTINE	KLKB1 →	+0.133	+1.735	.008	.003	2	2
SKIN	METTL2A →	+0.235	+1.110	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAH by Pole plasm assembly activity — BREAST

Explore this box plot interactively →