Pole plasm assembly

Across TCGA cell cohorts, RNA activity of the Pole plasm assembly pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAM1L1, BTBD19, and GCSAML, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pole plasm assembly activity versus TRAM1L1 in LARGE_INTESTINE (Pearson r = 0.84).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRAM1L1 →	+0.916	+1.710	.001	<.001	3	2
SKIN	BTBD19 →	+1.975	+1.578	.002	<.001	3	2
LUNG_NSCLC_LUAD	GCSAML →	-0.095	-1.847	.002	<.001	3	1
LARGE_INTESTINE	PSMA7 →	-0.639	-1.722	.003	<.001	3	1
LARGE_INTESTINE	MRGBP →	-0.939	-1.710	.009	<.001	3	1
LARGE_INTESTINE	MCM8 →	-1.035	-1.173	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007315 vs TRAM1L1 — LARGE_INTESTINE

Explore this scatter interactively →