Oocyte construction

Across TCGA patient cohorts, RNA activity of the Oocyte construction pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PARP1, ADAR, and VCL, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oocyte construction activity versus PARP1 in HNSC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PARP1 →	+0.487	+0.076	<.001	<.001	3	7
LSCC	ADAR →	+0.322	+0.104	<.001	<.001	3	6
BRCA	VCL →	-0.281	-0.038	.001	.004	3	6
BRCA	FLAD1 →	+0.364	+0.074	<.001	<.001	3	6
LSCC	CCDC97_S212 →	+0.291	+0.073	.008	<.001	3	6
LSCC	CDC73 →	+0.231	+0.078	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007308 vs PARP1 — HNSC

Explore this scatter interactively →