Oocyte construction

Across TCGA patient cohorts, RNA activity of the Oocyte construction pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCOLCE, MRC2, and COL5A1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oocyte construction activity versus PCOLCE in BRCA (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PCOLCE →	-1.015	-0.289	<.001	.001	3	3
BRCA	MRC2 →	-0.609	-0.217	.002	<.001	3	3
GBM	COL5A1 →	-1.183	-0.103	.002	<.001	3	3
BRCA	COL6A1 →	-0.909	-0.215	<.001	<.001	3	3
LUAD	TDRKH →	+0.515	+0.115	.001	.005	3	3
OV	SDCBP →	+0.493	+0.131	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007308 vs PCOLCE — BRCA

Explore this scatter interactively →