Oocyte construction

Across TCGA patient cohorts, RNA activity of the Oocyte construction pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MIER1_S377, NEK9_S801, and TDRKH, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oocyte construction activity versus MIER1_S377 in OV (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MIER1_S377 →	+0.694	+0.170	<.001	<.001	3	3
OV	NEK9_S801 →	-0.863	-0.131	<.001	<.001	3	3
COAD	TDRKH →	+0.578	+0.217	.002	.003	1	5
BRCA	ANKLE2_S662 →	+0.397	+0.242	<.001	<.001	3	3
UCEC	ANK2_S3765 →	-0.859	-0.478	<.001	<.001	3	3
UCEC	PALLD →	-0.803	-0.474	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007308 vs MIER1_S377 — OV

Explore this scatter interactively →