Oocyte construction

Across TCGA cell cohorts, RNA activity of the Oocyte construction pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAH, KCNE3, and KLHL7, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAH grouped by Oocyte construction-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FAH →	-0.420	-1.588	<.001	<.001	3	2
BREAST	KCNE3 →	-0.145	-1.645	.005	.006	3	2
LIVER	KLHL7 →	+0.120	+1.490	.006	.005	1	3
BREAST	ABCD1 →	+0.459	+1.588	.008	<.001	3	1
BREAST	VWA8 →	+0.206	+1.588	.001	<.001	3	1
BREAST	SEMA3G →	-0.400	-1.622	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAH by Oocyte construction activity — BREAST

Explore this box plot interactively →