Female gamete generation

Across TCGA cell cohorts, RNA activity of the Female gamete generation pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACOT8, PLXNA2, and MEIS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACOT8 grouped by Female gamete generation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ACOT8 →	+0.200	+0.105	.003	.001	3	5
LUNG_NSCLC_LUSC	PLXNA2 →	-0.212	-0.152	.003	.002	3	5
OESOPHAGUS	MEIS2 →	+0.084	+0.132	.002	.005	3	5
BREAST	GABRA1 →	+0.163	+0.112	.002	.005	3	5
CNS	RSPRY1 →	+0.274	+0.179	<.001	<.001	3	5
LUNG_SCLC	GLB1L2 →	-0.284	-0.114	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACOT8 by Female gamete generation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →