Female gamete generation

Across TCGA cell cohorts, RNA activity of the Female gamete generation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF484, BUD13, and DCAF7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Female gamete generation activity versus ZNF484 in BLOOD_Leukemia (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF484 →	+0.580	+0.504	<.001	.002	3	5
BREAST	BUD13 →	+0.495	+0.583	.007	.002	3	5
SOFT_TISSUE	DCAF7 →	+0.708	+0.804	<.001	.006	3	4
LARGE_INTESTINE	SLC9A6 →	+0.615	+0.505	<.001	.007	3	4
BLOOD_Leukemia	ABCD4 →	+0.949	+0.616	<.001	.002	3	4
BREAST	ARHGAP23 →	+2.161	+0.745	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0007292 vs ZNF484 — BLOOD_Leukemia

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